Hands-on Activity Engineering Digital Biodegraders for Biological Cleanup

Quick Look

Grade Level: 11 (11-12)

Time Required: 3 hours

(can be split into different sessions)

Expendable Cost/Group: US $0.00

Requires the use of computers, one per student pair.

Group Size: 2

Activity Dependency:

Subject Areas: Biology, Computer Science, Life Science, Science and Technology

NGSS Performance Expectations:

NGSS Three Dimensional Triangle
HS-ETS1-4
HS-LS4-4

This activity requires the resource(s):

Gloved hands hold two petri dishes with orange nutrient agar. One is covered in bacterial colonies and one has no colonies growing on it.
Traditional lab petri dishes with bacterial colonies.
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Summary

A hypothetical scenario is introduced in which the class is asked to apply their understanding of the forces that drive natural selection to prepare a proposal along with an environmental consulting company to help clean up an area near their school that is contaminated with trichloroethylene (TCE). Students use the Avida-ED software application to test hypotheses for evolving (engineering) a strain of bacteria that can biodegrade TCE, resulting in a non-hazardous cleanup solution. Conduct this design challenge activity after completion of the introduction to digital evolution activity, Studying Evolution with Digital Organisms.
This engineering curriculum aligns to Next Generation Science Standards (NGSS).

Engineering Connection

Computer scientists and engineers work together to create software and hardware to model complex systems and create new technologies. The digital evolution software, Avida, was created by a group of computer scientists and software engineers interested in the experimental study of digital organisms in order to better understand how biological natural selection works and then to apply that knowledge to solving computational problems. Evolutionary computation methods can be applied to solve a wide range of engineering design problems.

Learning Objectives

After this activity, students should be able to:

  • Explain how the process of natural selection leads to organisms that are well suited for the environment.
  • Discuss characteristics of the environment and organisms that influence the process of natural selection.
  • Develop and test a hypothesis and then use the data to draw conclusions.
  • Propose a protocol for critiquing proposed solutions to the problem.

Educational Standards

Each TeachEngineering lesson or activity is correlated to one or more K-12 science, technology, engineering or math (STEM) educational standards.

All 100,000+ K-12 STEM standards covered in TeachEngineering are collected, maintained and packaged by the Achievement Standards Network (ASN), a project of D2L (www.achievementstandards.org).

In the ASN, standards are hierarchically structured: first by source; e.g., by state; within source by type; e.g., science or mathematics; within type by subtype, then by grade, etc.

NGSS Performance Expectation

HS-ETS1-4. Use a computer simulation to model the impact of proposed solutions to a complex real-world problem with numerous criteria and constraints on interactions within and between systems relevant to the problem. (Grades 9 - 12)

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This activity focuses on the following Three Dimensional Learning aspects of NGSS:
Science & Engineering Practices Disciplinary Core Ideas Crosscutting Concepts
Use mathematical models and/or computer simulations to predict the effects of a design solution on systems and/or the interactions between systems.

Alignment agreement:

Both physical models and computers can be used in various ways to aid in the engineering design process. Computers are useful for a variety of purposes, such as running simulations to test different ways of solving a problem or to see which one is most efficient or economical; and in making a persuasive presentation to a client about how a given design will meet his or her needs.

Alignment agreement:

Models (e.g., physical, mathematical, computer models) can be used to simulate systems and interactions—including energy, matter, and information flows—within and between systems at different scales.

Alignment agreement:

NGSS Performance Expectation

HS-LS4-4. Construct an explanation based on evidence for how natural selection leads to adaptation of populations. (Grades 9 - 12)

Do you agree with this alignment?

Click to view other curriculum aligned to this Performance Expectation
This activity focuses on the following Three Dimensional Learning aspects of NGSS:
Science & Engineering Practices Disciplinary Core Ideas Crosscutting Concepts
Construct an explanation based on valid and reliable evidence obtained from a variety of sources (including students' own investigations, models, theories, simulations, peer review) and the assumption that theories and laws that describe the natural world operate today as they did in the past and will continue to do so in the future.

Alignment agreement:

Natural selection leads to adaptation, that is, to a population dominated by organisms that are anatomically, behaviorally, and physiologically well suited to survive and reproduce in a specific environment. That is, the differential survival and reproduction of organisms in a population that have an advantageous heritable trait leads to an increase in the proportion of individuals in future generations that have the trait and to a decrease in the proportion of individuals that do not.

Alignment agreement:

Empirical evidence is required to differentiate between cause and correlation and make claims about specific causes and effects.

Alignment agreement:

Scientific knowledge is based on the assumption that natural laws operate today as they did in the past and they will continue to do so in the future.

Alignment agreement:

  • Use appropriate tools strategically. (Grades K - 12) More Details

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  • Make sense of problems and persevere in solving them. (Grades K - 12) More Details

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  • Model with mathematics. (Grades K - 12) More Details

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  • Represent data on two quantitative variables on a scatter plot, and describe how the variables are related. (Grades 9 - 12) More Details

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  • Summarize, represent, and interpret data on two categorical and quantitative variables (Grades 9 - 12) More Details

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  • Biotechnology has applications in such areas as agriculture, pharmaceuticals, food and beverages, medicine, energy, the environment, and genetic engineering. (Grades 9 - 12) More Details

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  • Illustrate principles, elements, and factors of design. (Grades 9 - 12) More Details

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  • Make sense of problems and persevere in solving them. (Grades K - 12) More Details

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  • Model with mathematics. (Grades K - 12) More Details

    View aligned curriculum

    Do you agree with this alignment?

  • Use appropriate tools strategically. (Grades K - 12) More Details

    View aligned curriculum

    Do you agree with this alignment?

  • Summarize, represent, and interpret data on two categorical and quantitative variables (Grades 9 - 12) More Details

    View aligned curriculum

    Do you agree with this alignment?

  • Represent data on two quantitative variables on a scatter plot, and describe how the variables are related. (Grades 9 - 12) More Details

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    Do you agree with this alignment?

  • Describe a reason for a given conclusion using evidence from an investigation. (Grades 9 - 12) More Details

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  • Summarize the major concepts of natural selection (differential survival and reproduction of chance inherited variants, depending on environmental conditions). (Grades 9 - 12) More Details

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  • Explain how natural selection leads to organisms that are well suited for the environment (differential survival and reproduction of chance inherited variants, depending upon environmental conditions). (Grades 9 - 12) More Details

    View aligned curriculum

    Do you agree with this alignment?

  • Describe how natural selection provides a mechanism for evolution. (Grades 9 - 12) More Details

    View aligned curriculum

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  • Use a computer simulation to model the impact of proposed solutions to a complex real-world problem with numerous criteria and constraints on interactions within and between systems relevant to the problem. (Grades 9 - 12) More Details

    View aligned curriculum

    Do you agree with this alignment?

  • Construct an explanation based on evidence for how natural selection leads to adaptation of populations. (Grades 9 - 12) More Details

    View aligned curriculum

    Do you agree with this alignment?

Suggest an alignment not listed above

Materials List

Each group needs:

Worksheets and Attachments

Visit [www.teachengineering.org/activities/view/mis_avida_lesson01_activity2] to print or download.

Pre-Req Knowledge

A basic understanding of evolution by natural selection is required. This activity should be introduced only after completing the introductory Evolution of Digital Evolution lesson and the Studying Evolution with Digital Organisms activity.

Introduction/Motivation

Your school administrators want to buy an adjacent piece of property to build new athletic facilities. The property includes a large warehouse that has been used for various industrial purposes over the last 50 years. During the site inspection it was learned that the soil and water around the warehouse are contaminated by trichloroethylene (TCE), a hazardous chemical used as a spot remover in dry cleaning and as a degreaser for metal parts. The school board has asked our class to team up with an environmental consulting company to help cleanup the TCE so that our school can move ahead with purchasing and using the land.

(Continue by having students read aloud the complete hypothetical design challenge scenario as provided in the attached Evolving TCE Biodegraders Handout.)

Procedure

Before the Activity

  • Teacher to review the activities on in advance so that s/he can help direct students during class.
  • Prepare enough computers with Avida-ED installed for each pair of students.
  • Make copies of the Evolving TCE Biodegraders Handout, one per person. This handout provides the scenario, background information, and questions to guide students' experimental designs.

With the Students

  1. With student pairs each at computers that have Avida-ED installed, give each student a handout.
  2. As a class, read aloud the hypothetical design challenge scenario.
  3. Facilitate a class discussion to explore what students know about the problem and what they need to know about the problem.
  4. Read aloud the background information and the experimental design questions. Clarify any language in the questions so that the task is clearly defined—without providing any suggestions for how to solve the problem.
  5. Have students complete the experimental design questions, writing out their answers. Through this process, students:
    • develop hypotheses and predictions using the "if... then..." format
    • determine how much data to collect
    • write concise descriptions of their experimental design methods (including settings, replications, data collection, etc.) that are clear enough for replication by others
    • identify dependent and independent variables and the controls
    • organize their data into tables
    • determine the graph(s) for best data presentation
  1. Note: Students may choose to change one or more of the organism or environmental variables in order to influence the evolution of the "oro" function in the population. Students' protocols may go in a number of directions including changing only one variable at a time, changing multiple variables, evolving the "oro" function as quickly as possible using one set of parameters and then transplanting that organism to another environment to "clone" it, or using only one static set of parameters for the population. Permit students to pursue any of these options; as a group, discuss the pros and cons of each.
  2. Next, students collect data, documenting the parameters for each run and recording observations.
  3. Then students create graphs to display their results.
  4. Next, students describe how their results support/refute their hypotheses.
  5. Then students propose protocols for evolving bacteria to degrade TCE, including preparing short class presentations to explain their proposals.
  6. As a class, watch and listen to the group proposals.
  7. Facilitate a class discussion to determine which group proposal most effectively evolves efficient TCE degrading bacteria. Encourage students to critique the proposed protocols and come to a consensus about what should be presented to the environmental consulting company and why. Are there any unanswered questions? Do we feel confident submitting one of these proposals? Do we need to run more experiments? This should lead to a rich discussion about the nature of scientific inquiry and the engineering design process.

Vocabulary/Definitions

Avida-ED: An educational version of the digital evolution software, Avida. Avida-ED is an award-winning educational application developed for undergraduate biology courses to help students learn about evolution and the scientific method by enabling them to design and perform experiments to test hypotheses about evolutionary mechanisms using evolving digital organisms.

evolution: The change in the genetic composition of a population from generation to generation.

natural selection: A process in which organisms with certain inherited characteristics are more likely to survive and reproduce than are organisms with other characteristics; the main driving force of evolution.

Assessment

Activity Embedded Assessment

Handout Questions: Collect students' answers to the handout questions and/or the student-generated data and analysis as a source of formative assessment.

Data Summary Presentation: Grade the groups' oral class presentations, evaluating for subject matter comprehension, concise description of experimental design methodology, convincing presentation of proposed protocol to meet the design challenge, and overall clarity of communication. Alternatively, instead of oral presentations, have students create posters or other visual representations of the data.

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Copyright

© 2013 by Regents of the University of Colorado; original © 2011 Michigan State University

Contributors

Wendy Johnson; Amy Lark; Robert Pennock; Louise Mead

Supporting Program

Bio-Inspired Technology and Systems (BITS) RET, College of Engineering, Michigan State University

Acknowledgements

The contents of this digital library curriculum were developed through the Bio-Inspired Technology and Systems (BITS) RET program under National Science Foundation RET grant no EEG 0908810. However, these contents do not necessarily represent the policies of the NSF and you should not assume endorsement by the federal government.

Last modified: December 14, 2019

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